Whole blood coagulation in children with thrombocytopenia and the response to platelet replacement, recombinant factor VIIa, and a potent factor VIIa analogue

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Coagulation and Transfusion Medicine / RECOMBINANT FACTOR VIIA

Recombinant factor VIIa (rFVIIa) has become available for treating people with hemophilia with inhibitors who experience bleeding or require surgery. It has become apparent that rFVIIa is useful in controlling bleeding in a variety of clinical situations. This review attempts to collate and summarize the nonhemophilia applications of rFVIIa. The theoretical mechanism for the coagulation and hem...

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Recombinant Human Coagulation Factor VIIa for Intracerebral Hemorrhage.

with expanding intracranial bleeds associated with neurologic deterioration, or where urgent surgical intervention is indicated. Often, a single dose of 40 microg/Kg dramatically corrects the coagulopathy in minutes, allowing stabilization of clot expansion and safe neurosurgical intervention, while fresh frozen plasma, vitamin K and other products are administered for subacute maintenance of n...

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Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro.

BACKGROUND This study evaluates the effect of hemodilution by various common resuscitation fluids, and the efficacy of activated recombinant factor VII (rFVIIa) on coagulation parameters in human blood in vitro. METHODS Samples from normal healthy volunteers (n = 9) were hemodiluted from 0% to 90% with normal saline, or 0%, 40%, 60%, and 80% with 5% albumin, Hespan, Hextend, normal saline, or...

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Mechanism of factor VIIa-dependent coagulation in hemophilia blood.

The ability of factor VIIa to initiate thrombin generation and clot formation in blood from healthy donors, blood from patients with hemophilia A, and in anti-factor IX antibody-induced ("acquired") hemophilia B blood was investigated. In normal blood, both factor VIIa-tissue factor (TF) complex and factor VIIa alone initiated thrombin generation. The efficiency of factor VIIa was about 0.0001 ...

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Recombinant factor VIIa: safety and efficacy.

PURPOSE OF REVIEW Recombinant factor VIIa has been increasingly used to provide hemostasis in nonapproved indications. This trend has resulted in concerns about safety, efficacy and costs. RECENT FINDINGS Recombinant factor VIIa seems to have hemostatic effects in posttrauma and perisurgery excessive bleeding, although further studies are required. Recombinant factor VIIa may be used to rever...

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ژورنال

عنوان ژورنال: British Journal of Haematology

سال: 2009

ISSN: 0007-1048,1365-2141

DOI: 10.1111/j.1365-2141.2008.07439.x